Chapters
| Status | Drug name | NICE TAs | Comments |
|---|---|---|---|
|
Brivaracetam (Briviact ®) injection | ||
|
Brivaracetam (Briviact®) |
Initiation by Tertiary Epilepsy Specialist only. For adjunctive therapy in the treatment of partial-onset seizures with or without secondary generalisation in adult and adolescent patients from 16 years of age, with severe refractory epilepsy warranting tertiary specialist input for patients who have tried three or more AEDs. The patient has used levetiracetam and has documentation of intolerance and patient is using a third line agent (perampanel, zonisamide, lacosamide, eslicarbazepine) which would be replaced by brivaracetam. ESCA required. |
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Cannabidiol (Epidyolex®) | ||
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Carbamazepine M/R tablets |
Tegretol |
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Carbamazepine SF liquid |
Tegretol |
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Carbamazepine suppositories |
Tegretol |
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Carbamazepine tablets |
Tegretol |
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Cenobamate (Ontozry®) | ||
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Clobazam tablets |
MHRA Category 2: the need for continued supply of a particular manufacturer’s product should be based on clinical judgement and consultation with patient and/or carer, taking into account factors such as seizure frequency and treatment history |
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Clonazepam injection |
MHRA Category 2: the need for continued supply of a particular manufacturer’s product should be based on clinical judgement and consultation with patient and/or carer, taking into account factors such as seizure frequency and treatment history |
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Clonazepam tablets |
MHRA Category 2: the need for continued supply of a particular manufacturer’s product should be based on clinical judgement and consultation with patient and/or carer, taking into account factors such as seizure frequency and treatment history |
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Diazepam emulsion injection | ||
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Diazepam injection#4.8 | ||
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Diazepam rectal tubes | ||
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Eslicarbazepine tablets |
ESCA. MHRA - Category 2 |
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Ethosuximide capsules |
MHRA - Category 3 |
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Fenfluramine | ||
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Gabapentin capsules#4.8 | ||
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Gabapentin tablets#4.8 |
High relative cost |
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Lacosamide injection | ||
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Lacosamide syrup |
ESCA |
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Lacosamide tablets |
ESCA |
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Lamotrigine dispersible tablets | ||
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Lamotrigine tablets | ||
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Levetiracetam infusion | ||
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Levetiracetam SF oral solution | ||
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Levetiracetam tablets | ||
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Midazolam buccal liquid - buccolam | ||
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Oxcarbazepine suspension | ||
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Oxcarbazepine tablets | ||
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Paraldehyde rectal solution 50% in olive oil (10ml) | ||
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Perampanel tablets |
ESCA |
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Phenobarbital 50mg/5ml liquid (unlicensed) |
Ethanol free |
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Phenobarbital injection |
Hospital only |
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Phenobarbital tablets | ||
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Phenytoin capsules | ||
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Phenytoin sodium injection |
Hospital only |
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Phenytoin suspension | ||
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Pregabalin capsules |
Prescribers should prescribe generically. |
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Primidone tablets | ||
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Rufinamide tablets |
ESCA |
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Sodium valproate crushable tablets | ||
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Sodium valproate E/C tablets | ||
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Sodium valproate injection | ||
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Sodium valproate M/R tabs | ||
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Sodium valproate SF liquid | ||
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Stiripentol |
APC supports the continuation treatment in adults for those started as children (off label use). Inheriting BCH RAG status. |
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Toripamate tablets | ||
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Vigabatrin tablets |
ESCA |
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Zonisamide capsules |
