University Hospitals Birmingham NHS Foundation Trust

Reports

Status Drug name NICE TAs Comments
Status: Amber Methotrexate

ILD - ESCA

Status: Amber Methotrexate 2.5mg tablets

Supported with an ESCA. Methotrexate tablets - use 2.5mg strength ONLY. Methotrexate injection - Metoject is APC preferred brand. Check cytotoxic disposal arrangements locally.

Status: Amber Methotrexate injections

Supported with an ESCA. Metoject is APC preferred brand. Check cytotoxic disposal arrangements locally.

Status: Amber Methotrexate tablets (2.5mg)

ESCA. Methotrexate tablets - use 2.5mg strength only. Methotrexate injection - Metoject is APC preferred brand. Check cytotoxic disposal arrangements locally.

Status: Amber Methotrexate#13.5

ESCA

Status: Amber Methyldopa tablets
Status: Amber Methylphenidate tablets#Amber

ESCAs and additional advice in relation to age of patient and CCG

Status: Amber Metolazone

Specialist recommendation (unlicensed).

There is now a UK licensed metolazone 5mg tablet available (Xaqua®). There are significant differences in bioavailability between Xaqua® and alternative unlicensed imported metolazone preparations.

Xaqua® tablets have up to approximately twice the bioavailability of other metolazone preparations.

If switching from another metolazone product to Xaqua® tablets or vice versa, a dose adjustment may be necessary, and individualised titration based on patient's response and tolerability is advised.

More information available from Specialist Pharmacy Service (SPS). We are awaiting guidance on switching to the licensed product – in the mean time please ensure that the patients are not inadvertently switched between products.

Status: Amber Mexiletine hydrochloride 100mg & 200mg capsules

Unlicensed.

Use with local trust approval. Available from "Special order" manufacturers or specialist importing companies. 

Status: Amber Mezavant XL
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