Pathology tests database

Sample and container requirements

EDTA Plasma

Minimum volume required

300 µL plasma - users are asked to provide 1 mL of plasma to allow for repeat analysis if required

Special requirements

Samples should be received within the laboratory within 8 hours of collection.

Patient preparation

Biotin supplements should be stopped for at least 24 hours before sample collection. Ensure patient is not taking corticosteroids, synacthen and avoid undue stress. Take blood into EDTA tubes.

Sample viability

Turnaround time

5 days

Reference range

6 – 51 ng/L (Source: Immuno Diagnostic Systems)

Clinical guidance

Please refer to LabTestsOnlineUK to learn more about ACTH. https://labtestsonline.org.uk/tests/acth-test

Notes

Secretion of ACTH may be increased by stress. Some drugs and conditions can cause ACTH levels to rise, including amphetamines, insulin, levodopa, and metoclopramide. Drugs that cause ACTH to fall include dexamethasone and other drugs that act like cortisol (including prednisone, hydrocortisone, prednisolone, and methylprednisolone), and megestrol acetate.