Bicarbonate (CO2, HCO3-)
Clinical Biochemistry
Sample and container requirements
Serum Lithium Heparin Plasma (paediatrics only)
Minimum volume required
Special requirements
None
Patient preparation
None
Sample viability
Turnaround time
This assay is run throughout the day and night. The in-lab turnaround time is normally less than 24 hours.
Reference range
Neonate – 16 years: 19 – 28 mmol/L Adults: 22 – 29 mmol/L (Source: Pathology Harmony Recommendations)
Clinical guidance
Serum/Plasma bicarbonate measurements, combined with pH measurement are frequently used to diagnose and treat irregularities in acid-base imbalance. Please refer to LabTestsOnlineUK to learn more about bicarbonate. https://labtestsonline.org.uk/tests/bicarbonate
Notes
Artefactual decrease in bicarbonate can occur when samples are delayed in transit or if samples have been decapped for a prolonged period of time.
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This information was last updated on 19 August 2026