Pathology tests database

Sample and container requirements

Serum Lithium Heparin Plasma (paediatrics only)

Minimum volume required

Special requirements

None

Patient preparation

None

Sample viability

Turnaround time

This assay is run throughout the day and night. The in-lab turnaround time is normally less than 24 hours.

Reference range

Adults: <6 μmol/L Pregnancy: <9 μmol/L (Source: Abbott Diagnostics)

Clinical guidance

Bile acids are produced in the liver from cholesterol and stored in the gallbladder before being released into the small intestine, where they aid the digestion and absorption of dietary fats. The total serum bile acid concentration reflects synthetic, excretory and re-absorptive functions of the liver. Bile acid measurement is useful in the diagnosis of disorders of the hepatobiliary system. Bile acids are increased in patients with acute hepatitis, chronic hepatitis, liver sclerosis and liver cancer. Measurement of serum bile acids is primarily used in the investigation of intrahepatic cholestasis of pregnancy (ICP). In ICP, serum bile acid concentrations are typically increased and may become abnormal before changes are seen in routine liver function tests, making bile acid measurement a sensitive marker for the condition.

Notes