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Chromogranin A/B

Clinical Biochemistry

Sample and container requirements

EDTA Plasma

Minimum volume required

1 mL plasma

Special requirements

Fasting sample. Centrifuge the blood within 30 minutes of venepuncture. Send frozen.

Patient preparation

Fasting sample (6 - 8 hours) required.

Sample viability

Turnaround time

28 days

Reference range

Please refer to report for reference ranges.

Clinical guidance

Please follow the link below to the referral laboratory website for more information: https://www.nwlpathology.nhs.uk/test/chromagranin-a/ Please note, chromogranin B does not generally offer any additional clinical utility. Requesting chromogranin A measurement is sufficient for the investigation and monitoring of neuroendocrine tumours. Specimen requirements for chromogranin B measurement are the same as for chromogranin A. Monaghan, P.J., Lamarca, A., Valle, J.W., Hubner, R.A., Mansoor, W., Trainer, P.J. and Darby, D., 2016. Routine measurement of plasma chromogranin B has limited clinical utility in the management of patients with neuroendocrine tumours. Clinical endocrinology, 84(3), pp.348-352.

Notes

Sent to Charing Cross Hospital

Images to go here

This information was last updated on 19 August 2026