Pathology tests database

Sample and container requirements

Serum

Minimum volume required

4 ml Blood

Special requirements

none

Patient preparation

None

Sample viability

Store at 4oC

Turnaround time

5 days

Reference range

Negative

Clinical guidance

Ro and La are a heterogeneous antigenic complex made up of 52 kDa Ro, 60 kDa Ro and four small RNA particles . Anti-Ro are the most common ENA specificity amongst autoimmune diseases. They can be seen in Sjogren's syndrome, SLE, cutaneous lupus erythematosus, neonatal lupus and primary biliary cirrhosis.Anti-La (SS-B) antibodies are found mainly in Sjogren's syndrome and sometimes in SLEAnti-RNP antibodies can be seen in mixed connective tissue disease with a lower frequency in SLE . These antibodies are associated with a positive coarse speckled antinuclear antibody.Anti-Sm (Smith) antibodies are specific for SLE (5-30%) and are more prevalent in Afro-carribeans. Anti-Scl-70 antibodies are found in progressive systemic sclerosis and in limited scleroderma. Anti-Jo-1 antibodies are specific for adults with autoimmune myositis and idiopathic inflammatory myopathies. The antinuclear antibody result is usually negative although a faint cytoplasmic staining may be seen. https://labtestsonline.org.uk/tests/ena-panel

Notes