Pathology tests database

Sample and container requirements

Serum

Minimum volume required

4 ml Blood

Special requirements

none

Patient preparation

None

Sample viability

Store at 4oC prior to sending to referral lab

Turnaround time

14 days

Reference range

Range provided by reference laboratory Normal range (IgG & IgM) <1/500

Clinical guidance

Gangliosides are sialylated glycosphingolipids present in the outer membranes of many cells. The highest concentrations are found in the central and peripheral neuronal tissues. Autoantibodies to gangliosides have been demonstrated in many patients with peripheral neuropathies. The presence of antibodies has a direct contribution to the pathogenesis of the disorders and clinical status can be related to antibody titre. Both IgM and IgG antibodies are clinically useful although of limited disease specificity. They have limited diagnostic potential and are best used as circumstantial evidence to support a clinical diagnosis and to monitor disease activity.

Notes

UoB