Histone Antibodies
Immunology
Sample and container requirements
Serum
Minimum volume required
4 ml Blood
Special requirements
none
Patient preparation
None
Sample viability
Store at 4oC prior to sending to referral lab
Turnaround time
10 days
Reference range
Normal result = <40 U/mL
Clinical guidance
Anti-histone antibodies are found in patients with SLE and patients with DIL. In SLE, anti-histone antibodies do not provide any better diagnostic information than DNA and anti-nuclear antibodies but in drug induced lupus, a typical antibody profile consists of anti-nuclear antibodies, anti-histone antibodies but rarely dsDNA antibodies and extractable nuclear antibodies
Notes
Sheffield
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This information was last updated on 19 August 2026