Pathology tests database

Sample and container requirements

Serum

Minimum volume required

1 ml Serum

Special requirements

none

Patient preparation

none

Sample viability

Store at 4oC prior to sending to referral lab

Turnaround time

21 days from receipt at referral laboratory

Reference range

Negative

Clinical guidance

Muscle specific tyrosine kinase (MUSK) is a surface membrane enzyme that is essential in aggregating Acetylcholine receptor during the development of the neuromuscular junction. Recent studies have shown that antibodies to Musk are present in 40% to 50% of patients with generalized Acetylcholine Receptor seronegative MG. Anti-Musk antibodies have not been found in patients with purely ocular myasthenia or in those with anti-acetylcholine receptor antibodies. https://www.ouh.nhs.uk/immunology/diagnostic-tests/tests-catalogue/musk-antibodies/

Notes

Oxford