Pathology tests database

Sample and container requirements

Serum

Minimum volume required

1 ml Serum

Special requirements

None

Patient preparation

None

Sample viability

Store at 4oC prior to sending to referral lab

Turnaround time

14 days from receipt at referral laboratory

Reference range

Negative

Clinical guidance

Myelin oligodendrocyte glycoprotein (MOG) is a dominant target for demyelinating autoantibodies in multiple sclerosis (MS). Antibody-mediated demyelination is complement and/or antibody-dependent cell-mediated cytotoxicity (ADCC) dependent. Pathogenic MOG-specific antibodies recognize cell surface and largely conformation-dependent epitopes. The prevalence of anti-MOG antibodies in pediatric MS/acute disseminated encephalomyelitis (ADEM) patients suggests these contribute to demyelination in these diseases. https://www.ouh.nhs.uk/immunology/diagnostic-tests/tests-catalogue/myelin-oligodendrocyte-glycoprotein-antibodies/

Notes

UoB