Pathology tests database

Sample and container requirements

Serum

Minimum volume required

4 ml Blood

Special requirements

None

Patient preparation

None

Sample viability

Store at 4oC prior to sending to referral lab

Turnaround time

14 days

Reference range

Negative

Clinical guidance

Paraneoplastic antibodies are associated with a variety of neurological manifestations that are also associated with, and may be reactive with, an underlying malignancy. The demonstration of these antibodies may initiate a search for covert malignancy. In some cases tumour elimination may result in the reduction in antibody levels and the amelerioration of associated syndromes. Anti-Yo (PCA1) antibodies; associated tumour = Breast and ovarian carcinomas (Anti-Yo antibodies are usually only found in female patients); neurological syndrome = Cerebellar degeneration. Anti-Hu (ANNA1) antibodies; associated tumour = small cell lung carcinoma and neuroblastoma; neurological syndrome = cerebellar ataxia, paraneoplastic encephalomyelitis/sensory neuropathy. Anti-Ri (ANNA2) antibodies; associated tumour = breast, small cell lung carcinoma, gynaecological; neurological syndrome = opsoclonus/myclonus, paraneoplastic cerebellar degeneration, brainstem encephalomyelitis. https://sheffieldlaboratorymedicine.nhs.uk/search-test.php?search=3045&testname=Cerebellum%20(Purkinje)%20Cell%20Antibody%20IIF%20Screen%20(Hu,%20Ri,%20Yo,%20Tr,%20CV2,%20Ma/Ta),%20Neuronal%20Antibody

Notes

http://www.birmingham.ac.uk/facilities/clinical-immunology-services/index.aspx