Pathology tests database

Sample and container requirements

Serum

Minimum volume required

4 ml Blood

Special requirements

None

Patient preparation

None

Sample viability

Store at 4oC prior to sending to referral lab

Turnaround time

28 days from receipt at referral laboratory

Reference range

37.1 mg/L at week 6 18.4 mg /L at week 14 12.7 mg/L during maintenance treatment.

Clinical guidance

Vedolizumab is  Gut selective Integrin blocker used in the treatment of inflammatory bowel diseases such as Crohn's disease and Ulcerative colitis. Unlike other biologics used to treat these conditions such as  anti TNF alpha drugs, Vedolizumab is selective fro the gut and so has less systemic side effects.Trough levels of the drug may give an indication as to the possible outcome of the treatment as higher levels of drug during induction are associated with better clnical and endoscopic outcome. Low level of the drug can also indicate treatment failure, and when this falls below the detectable range anti drug antibodies may be measured.

Notes

https://www.exeterlaboratory.com/test/vedolizumab-drug-levels/